Numerous studies have reported an association of perioperative NT-proBNP levels with postoperative heart failure and reduced left ventricular function after coronary artery bypass grafting (CABG).7, 8, 9 A post hoc analysis of the EXCEL trial showed that high baseline NT-proBNP levels in patients with left main disease undergoing revascularization were independently associated with long-term mortality.10 This evidence concerns the gene NPPB and heart failure.