This simulationresult offers a plausible explanation for the larger amount of PHFsthan SFs in the frontal cortex of a patient with AD, which resultedin higher-resolution cryo-EM structures of PHFs than SFs.,, The fibrillar core of tau degradesmore rapidly and thoroughly under oeEFs with frequencies of 1 and0.1 GHz rather than 10 GHz. The gene discussed is MAPT; the disease is Alzheimer disease.