CCND1 and breast cancer: On the other hand, although not directly for HTX, OLE has been shown to be a potent inhibitor of cell proliferation in neuroblastoma [50] and breast cancer cells, delaying the cell cycle in the S phase and negatively regulating NF-κB and cyclin D1; HTX and OLE polyphenols can interfere with E2-dependent cell proliferation in breast cancer cells [120] (Figure 4).