E2F1 and colorectal carcinoma: After identifying that MYC, p65/RELA, TP53, P21/CDKN1A, E2F1, and EIF4E have been shown to interact with PRMT5 and KRAS in the STRING database, we then used the Gene Expression Profiling Interactive Analysis (GEPIA) database to determine which of the remaining proteins are overexpressed in CRC patient tumor samples compared to normal colon and rectum patient samples.