After conducting a literature review, a protein interaction analysis using the STRING database, a gene expression analysis using the GEPIA database, as well as a correlation analysis using the GEPIA database, we identified three critical proteins—MYC, E2F1, and EIF4E—that have been shown to have interactions with PRMT5 and KRAS in the STRING database, overexpressed gene expression in CRC patient tumor samples, as well as positively correlated gene expression with PRMT5 and KRAS in CRC patient tumor samples. This evidence concerns the gene EIF4E and neoplasm.