STAT3 and cancer: Figure S5B delineates the top 20 signaling pathways identified, which predominantly encompass pathways related to cancer, proteoglycans in cancer, the PI3K-Akt signaling pathway, the MAPK signaling pathway, and the EGFR tyrosine kinase pathway. Furthermore, the top 100 breast cancer-related genes, including PIK3CA, SRC, EGFR, AKT1, and STAT3, were identified from a protein–protein interaction (PPI) network comprising the 1747 breast cancer-associated genes, based on their degree centrality, as depicted in Figure S5C.