The results showed that ARSHs exerted anti-RA effects through bidirectional regulation of pro-inflammatory/anti-inflammatory factor balance (inhibition of IL-1β/IL-6/IL-17A and promotion of IL-4/IL-10), and their mechanisms may be related to the regulation of NF-κB, JAK/STAT, and other pathways [26,27,28], further validating alkaloids as the core active component of RSH. Here, NFKB1 is linked to rheumatoid arthritis.