Molecular docking of seven ARSH components (dihydrochelerythrine, magnoflorine, etc.)with core targets (SRC, STAT3, MAPK3) based on network pharmacological screening showed that dihydrochelerythrine, magnoflorine, and nitidine chloride possessed strong binding activities (affinity < −7.0 kcal/mol), corroborating their multi-component–multi-target synergistic anti-RA potential. Here, STAT3 is linked to rheumatoid arthritis.