C5AR1 and colorectal carcinoma: Subsequently, we used univariate the Cox regression analysis method to identify six genes that were significantly correlated with CRC patients’ overall survival (OS) from intersection genes (Figure 3G,H), and by Lasso regression analysis, six genes were selected to establish MIPM using the expression of genes weighted by the Lasso regression coefficient as follows: MIPM risk score = (0.077 × exp(C5AR1)) + (−0.141 × exp(CCR7)) + (−0.359 × exp(ICOS)) + (−0.191 × exp(IL2RB)) + (0.340 × exp(NRP1)) + (0.191 × exp(VIM)).