In addition to its functions affecting oncogenic transformation, such as facilitating the adaptation of tumor cells to a hypoxic environment by activating HIFs, supporting angiogenesis by interacting with bFGF and VEGF, and helping tumor cells escape from the immune system and apoptosis, PAK1 has a role in many signaling pathways [11,12,13,14,15]. The gene discussed is VEGFA; the disease is neoplasm.