In their study, they have found that Chemerin, α-defensin 1, and TNF-α in saliva are effective in detecting early stages of CRC, with salivary concentrations of all analyzed cytokines showing 100% sensitivity and 100% specificity, showing to be suitable markers in the diagnosis of CRC, particularly in the initial diagnosis of CRC using tests which measure the concentration of proteins (antigens) in saliva [68]. This evidence concerns the gene RARRES2 and colorectal carcinoma.