In addition, sesquiterpene lactones, such as alantolactone and isoalantolactone, from Inula helenium have been reported to induce intrinsic apoptosis in thyroid cancer and oral squamous carcinoma cells through ROS generation, BAX/BCL-2 ratio modulation, and caspase-3 activation [46,47]. The gene discussed is CASP3; the disease is thyroid gland carcinoma.