BAX and thyroid gland carcinoma: In addition, sesquiterpene lactones, such as alantolactone and isoalantolactone, from Inula helenium have been reported to induce intrinsic apoptosis in thyroid cancer and oral squamous carcinoma cells through ROS generation, BAX/BCL-2 ratio modulation, and caspase-3 activation [46,47].