Wanhong He et al. (2024) identified 52 methylation-driven DNA damage-response (DDR) genes with abnormal promoter methylation and expression in ovarian cancer; among these, BRCA1, PTTG1, TTK, AURKA, CDC6, and E2F1 were significantly associated with HRD scores, while E2F1, PTTG1, and CDC6 were also linked to PARP inhibitor sensitivity [130]. This evidence concerns the gene E2F1 and ovarian cancer.