Given the complexity of HRD biomarkers, key assay features include the selection of HRR genes (BRCA1, BRCA2, PALB2, RAD51C, RAD51D), definitions of genomic scars (LOH, TAI, LST), mutational signatures analyzed, use of comparator samples, and tumor-specific HRD score calculations. Here, PALB2 is linked to neoplasm.