On the other hand, a deficiency of TLR2 in diet-induced obesity in animal models favors a reduction in tissue inflammation, such as in the liver and adipose tissue, by reducing macrophage infiltration, enhancing insulin sensitivity, glucose tolerance, and reducing obesity despite average food intake compared to wild type mice [80,81,82]. Here, TLR2 is linked to obesity due to melanocortin 4 receptor deficiency.