In MS, ATAD3A, POLG, and TIMM21 were pivotal in mitochondrial genetic information processing, with ALDH4A1 and ALDH7A1 highlighting amino acid metabolism, and FKBP8 underscoring mitochondrial morphology and quality control, reflecting immune-mediated damage to mitochondrial structural and functional dynamics. This evidence concerns the gene ALDH7A1 and myeloid sarcoma.