Finally, BCL2L1 (Total Importance: 8.62 in MS, 7.38 in ALS) was protective in MS (OR: 0.999; 95% CI: 0.998–0.999; p = 2.80 × 10−7) but increased ALS risk (OR: 1.071; 95% CI: 1.031–1.113; p = 0.0005), highlighting its role in mitochondrial dynamics and apoptosis. Here, BCL2L1 is linked to amyotrophic lateral sclerosis.