For MS, diverse pathways, including mitochondrial metabolic processes (Score 0.836), mitochondrial signaling cascades (0.832), and mitochondrial lipid biosynthesis and catabolism (0.829), were predictive, with leading genes ATAD3A (56.0), involved in mitochondrial DNA organization; POLG (49.4), a mitochondrial DNA polymerase; and ALDH4A1 (44.8), an amino acid metabolism enzyme. This evidence concerns the gene POLG and myeloid sarcoma.