PDK1 (Total Importance: 21.85 in AD, 9.31 in ALS) increased risk in both AD (OR: 1.041; 95% CI: 1.001–1.082; p = 0.042) and ALS (OR: 1.037; 95% CI: 1.006–1.068; p = 0.019), implicating altered pyruvate metabolism. Here, PDK1 is linked to amyotrophic lateral sclerosis.