PNKD (Total Importance: 27.55 in ALS, 9.26 in PD) and ACAD9 (Total Importance: 18.40 in ALS, 9.97 in PD) were linked to OXPHOS assembly factors, with PNKD showing reduced risk in ALS (OR: 0.966; 95% CI: 0.946–0.986; p = 0.001) but increased risk in PD (OR: 1.088; 95% CI: 1.025–1.154; p = 0.005). This evidence concerns the gene ACAD9 and Parkinson disease.