PDK4 and amyotrophic lateral sclerosis: Compounds targeting PDK1 and PDK4, such as N-(2,3-Dimethylphenyl)-2-((3-(2-hydroxyphenyl)-1H-1,2,4-triazol-5-yl)thio)acetamide (PUBCHEM_CID: 1116656) and Ver-246608 (PUBCHEM_CID: 86280454), showed a combined importance of 47.7 for AD and ALS, implicating mitochondrial carbohydrate and pyruvate metabolism as critical therapeutic targets.