In ALS, pathways related to energy transduction and mitochondrial integrity were prominent, such as oxidative phosphorylation (Score 0.761), composition and assembly of oxidative phosphorylation subunits (0.755), and mitochondrial morphology and quality control (0.733), with top genes NUBPL (88.1), a Complex I assembly factor; ATP5ME (82.7), an ATP synthase subunit; and SLC25A20 (67.7), a carnitine/acylcarnitine carrier. The gene discussed is ATP5ME; the disease is amyotrophic lateral sclerosis.