PGS1 (Total Importance: 9.43 in AD, 11.21 in ALS) was found to protect against AD (OR: 0.931; 95% CI: 0.868–0.998; p = 0.045) and ALS (OR: 0.914; 95% CI: 0.869–0.962; p = 0.001) by contributing to cardiolipin synthesis in AD and phospholipid metabolism in ALS, with reduced risk in both diseases. The gene discussed is PGS1; the disease is amyotrophic lateral sclerosis.