TP53 and osteosarcoma: An important feature of genomic instability is chromothripsis that can be observed in approximately 77% of osteosarcoma, that generates massive fragmentation and reassembly of the genome often leading to amplifications (e.g., CDK4, MDM2), gains (RICTOR, TERT), and disruptions (TP53, NF1) of chromosomal loci 5, 6, 12, 13, 14, and 17 [24].