TGFB1 and neoplasm: It is also important to highlight the immune features of the TME that are associated with the immunosuppressive elements, which include the following: tumor-associated macrophages (TAMs); neutrophils (TANs); myeloid-derived suppressor cells (MDSCs); regulatory T cells (Tregs); and key immunoregulatory molecules such as PD-1, IL-10, TGF-β, vascular endothelial growth factor (VEGF), and STAT3.