ITPR1 and hyperlipidemia: In preadipocytes, Fyn phosphorylates inositol (1,4,5)-trisphosphate receptor 1(IP3R1), thereby mediating lysosomal calcium ion overload in response to upregulation of CD36, which promotes inflammation in adipose tissue [60]; in microglia, Fyn mediates CD36-induced mitochondrial dysfunction and activation of the Nod-like receptor protein 3 (NLRP3) inflammasome in response to α-synuclein, though the relevance of this mechanism to hyperlipidemia-associated inflammation requires further investigation [61].