ESR1 and alopecia: In the protein–protein interaction (PPI) analysis, nine target proteins with relatively high degree values and strong relevance to alopecia were selected for docking, namely AKT1 (3cqu), ESR1 (1YIM), IL1B (3POK), BCL2 (2O22), TGFB1 (6P7J), CASP3 (1RHJ), PPARG (2GTK), AR (2AM9), MPO (5MFA), along with 16 small molecules (Table 2).