In hepatocellular carcinoma cell lines (HepG2 and Huh7), CNOT2 deficiency was found to enhance the antitumor effects of MID1IP1 depletion while reducing apoptosis markers, suggesting a functional interplay between CNOT2 and MID1IP1 in liver cancer cells [17]. This evidence concerns the gene CNOT2 and hepatocellular carcinoma.