The upregulation of RPL5 or RPL11 is regulated through the depletion of MID1IP1, and the depletion of RPL5 and RPL11 activates c-Myc in MID1IP1-depleted HepG2 and Huh7 cells, suggesting that RPL5 and RPL11 are responsible for the regulation of c-Myc as tumor suppressors [17]. This evidence concerns the gene RPL11 and neoplasm.