PPARGC1A and familial dilated cardiomyopathy: For example, secreted frizzled-related protein 2 (SFRP2) reduced oxidative stress in DCM by regulating AMPK-PGC1 signaling and then exerted cardioprotective effects [207], indicating that targeting oxidative stress and its relative signaling pathways is a reliable way to find new approaches in the treatment of DCM.