The consequences are threefold: metabolic deterioration through β-cell dysfunction and insulin resistance [136,139,140], direct biomolecular damage [141], and accelerated vascular injury—manifesting as retinopathy, nephropathy, neuropathy, and cardiovascular disease—through oxidative–inflammatory crosstalk mediated by the ICAM-1 and NLRP3 inflammasomes [142,143]. This evidence concerns the gene NLRP3 and Insulin resistance.