Clinical studies further confirm that quercetin supplementation (≥500 mg/day for ≥8 weeks) in humans significantly improves FBG, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), and levels of the aforementioned inflammatory markers (e.g., TNF-α and IL-6) in patients with T2DM and metabolic syndrome. The gene discussed is TNF; the disease is type 2 diabetes mellitus.