Supporting these observations, Li et al. demonstrated that N-acetylcysteine (NAC), a precursor of the endogenous antioxidant glutathione (GSH), alleviated myocardial I/R injury in diabetic models by upregulating DJ-1 expression and enhancing activation of the PTEN/Akt signaling cascade [35] in T1DM. This evidence concerns the gene PARK7 and type 1 diabetes mellitus.