Studies on tongue squamous cell carcinoma cell lines showed increased reactive oxygen species (ROS) production, caspase-3 activation, and gasdermin E (GSDME) cleavage by docetaxel (this chemotherapeutic agent promotes apoptosis via the ROS/caspase-3/GSDME pathway) [36]. The gene discussed is CASP3; the disease is tongue squamous cell carcinoma.