NLCs also express BAFF (CD257) and APRIL (CD258), proteins of the TNF family that activate TNF-family receptors on CLL cell-like calcium-modulators and cyclophilin ligand (CAML) interactors, B-cell maturation antigens (BCMAs), or BAFF-receptors and activate NF-κB [40]. This evidence concerns the gene TNFRSF13C and B-cell chronic lymphocytic leukemia.