AGT and hypertensive disorder: Moreover, due to the complex SFO molecular network that senses and integrates circulating signals, alterations in the SFO are implicated in the development of cardiovascular diseases encompassing several neurogenic forms of hypertension, including angiotensin-II (Ang-II) [36] and deoxycorticosterone acetate-salt-dependent hypertension [37], as well as heart failure [38].