A further layer of complexity is added by the positive feedback between NLRP3 and the IL-4 promoter, particularly in malignant CD4+ T cells of cutaneous T cell lymphoma, which perpetuates high IL-4 production and reinforces the Th2-dominant, immunosuppressive environment [46]. The gene discussed is NLRP3; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.