In summary, our data indicate that KD feeding induces fibrosis and MASH through upregulated Il-6, Tnf, and Mapk13 pathways at TN, whereas adipocyte-specific gp130 deletion prevents KD-induced hepatic steatosis through reduced p-HSL, p-JNK, and p-p38 MAPK signaling. The gene discussed is LIPE; the disease is Hepatic steatosis.