Given that RNAseq analysis identified upregulated IL-6 and JNK signaling in KD-induced MASH and fibrosis, we investigated whether liver IL-6-gp130 disruption could alleviate KD-induced MASLD and insulin resistance in liver-specific gp130 knockout (gp130∆alb) mice and littermate controls (gp130F/F), generated using the Cre-lox system. Here, MAPK8 is linked to metabolic dysfunction-associated steatotic liver disease.