Given that RNAseq analysis identified upregulated IL-6 and JNK signaling in KD-induced MASH and fibrosis, we investigated whether liver IL-6-gp130 disruption could alleviate KD-induced MASLD and insulin resistance in liver-specific gp130 knockout (gp130∆alb) mice and littermate controls (gp130F/F), generated using the Cre-lox system. The gene discussed is IL6; the disease is Insulin resistance.