CEACAM5 and colorectal carcinoma: Previous studies have demonstrated that incorporating tumor markers improves the accuracy of preoperative prognostic models.27,28 In addition, among patients with stages I to III CRC, models additionally integrating perioperative longitudinal CEA and CA19-9 measurements exhibit markedly enhanced prognostic accuracy.29 However, the significance of dynamic change of longitudinal preoperative and postoperative CEA and CA19-9 for the estimation of prognoses among patients with CRLM is unclear.