FN1 and Sepsis: This reduction in circulating fibronectin levels during sepsis has been proposed to occur through multiple mechanisms, including decreased hepatic synthesis, intravascular consumption through proteolytic degradation, phagocytosis of opsonized particles, incorporation into fibrin clots during disseminated intravascular coagulation (DIC), and redistribution into the extravascular space where it binds to inflamed or injured tissue [31, 33].