The establishment of prognostic model was based on the expression levels of 14 SASP-related genes, including ASPRV1, ICAM1, IL2RA, ABCC2, HLA-B, TPMT, ATM, CD59, KIR2DL4, CTLA4, ITGB3, FOXM1, NOX4, and TRIM21. Patients with melanoma who were in the high-risk group had a shorter overall survival (OS), indicating that the model served as an independent prognostic index. This evidence concerns the gene NOX4 and melanoma.