Lasso regression was used to perform dimensionality reduction and a total of 14 genes including ASPRV1, ICAM1, IL2RA, ABCC2, HLA-B, TPMT, ATM, CD59, KIR2DL4, CTLA4, ITGB3, FOXM1, NOX4, and TRIM21 were selected to calculate the risk score for patients with melanoma (Fig. 1D, E). This evidence concerns the gene CTLA4 and melanoma.