Moreover, Bar-Peled et al. demonstrated that NR0B1, which is a strictly NRF2-regulated protein, supporting the anchorage-independent growth of KEAP1-mutant NSCLC cells forms a multimeric transcriptional complex important for regulating a subset of the NRF2 gene expression program in NSCLC cells [7]. Here, KEAP1 is linked to non-small cell lung carcinoma.