To sum up, Zc3h11a promotes the myopia-associated factor Tgfβ1 by acting directly or indirectly on both the PI3K-AKT and NF-κB signaling pathway-mediated stress reactions and the expression of Mmp2 and Il6, which together, caused the development of early HM (Figure 8). The gene discussed is ZC3H11A; the disease is myopia.