Evidence suggests that the dengue virus induces pathophysiological alterations in all hemostasis components, leading to abnormal von Willebrand factor (VWF) multimers, vasculopathy, thrombocytopenia, thrombopathy, reduction of several coagulation factors, increased antifibrinolytic factors, and consumption of natural anticoagulants. This evidence concerns the gene VWF and Thrombocytopenia.