Polymorphisms in ESR1, such as PvuII (rs2234693 T > C), XbaI (rs9340799 A > G), and T594T (rs2228480 G > A), have been reported to be significantly associated with cancer development, particularly in HCC and prostate cancer, as confirmed by this study [58,59]. The gene discussed is ESR1; the disease is Familial prostate cancer.