The osteoarthritis pathway appears to be driven through increased expression of select osteogenic transcription factors including osx, cepb-β, and dlx5 in conjunction with dysregulation of several upstream cell signaling modulators associated with osteogenesis including mantn, grem1, bmp, FGF, Apelin, and wnt (Supplemental Figure S2). The gene discussed is GREM1; the disease is osteoarthritis.