In particular, recent evidence from a systematic review and network meta-analysis by García-Hermoso et al. [61] demonstrated that high-intensity interval training (HIIT), especially when combined with resistance training, produced the greatest reductions in insulin resistance markers such as fasting insulin and homeostatic model assessment for insulin resistance (HOMA-IR) in children and adolescents with overweight or obesity. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.