PIEZO2 and channelopathy: The primary damage phase of the neurocentric DOMS mechanism theory may be initiated by a Piezo2 channelopathy on Type Ia proprioceptive terminals within the muscle spindle, leading to the secondary damage phase with harsher tissue damage in the extrafusal space, with the involvement of wide dynamic range (WDR) neurons on the spinal dorsal horn and other ion channels [9].