APC and neoplasm: Aberrant expression of APC, along with LINC01133 expression, suggests an influence of the lncRNA on tumor suppressor activity, inhibiting neoplastic cell proliferation; (ii) the expression of mutated TP53 genes and inhibition of the expression of wild-type TP53 copies is one of the main factors leading to cell cycle deregulation and the onset and maintenance of tumors [62].