ROS generation in AD is both a cause and an effect of nuclear factor erythroid 2-related factor 2 (Nrf2) activation through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/glycogen synthase kinase 3 beta (GSK3β), p62, p38, Mitogen-Activated Protein Kinase (MAPK)/Nuclear Factor kappa-light-chain-enhancer of activated B cell (NF-Κb) pathways, which are deeply associated with AD pathogenesis [191]. This evidence concerns the gene GSK3B and Alzheimer disease.