NOS2 and Alzheimer disease: Among them, butyrolactone I was found to inhibit the production of NO and interleukin-1 β (IL-1β), reduce the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), inhibit the phosphorylation of nuclear factor kappa-B (NF-κB) in BV2 cells induced by lipopolysaccharide (LPS), and improve the memory of AD model zebrafish injured by AlCl3 [15,16].