Large-scale functional screening of a heterogeneous CRC-PDO biobank and paired healthy colonic mucosa samples resulted in the generation of MCLA-158, a dual-targeting bispecific antibody that induces EGFR degradation in leucine-rich repeat-containing G-protein-coupled receptor 5-positive (LGR5+) cancer stem cells with minimal toxicity toward healthy LGR5+ colon stem cells [25]. This evidence concerns the gene LGR5 and colorectal carcinoma.