The National Comprehensive Cancer Network (NCCN) classification considers high-risk parameters the evidence of extraprostatic extension (clinical T-stage T3a), Gleason score ≥ 8, and PSA ≥ 20 ng/mL, with locally advanced disease (stage cT3b-T4) described as very high-risk PC, instead [9]. The gene discussed is KLK3; the disease is pachyonychia congenita.