First, aggressive forms of PC drive a high risk of occult micrometastatization (regional and extra-regional lymph nodes, but also distant metastases), which is managed with higher accuracy than in the past thanks to the development of functional imaging with highly prostate tumor-specific radiotracers, namely prostate-specific membrane antigen (PSMA)–positron emission tomography (PET)/computed tomography (CT) [11]. The gene discussed is FOLH1; the disease is pachyonychia congenita.