Of note, the Radiation Therapy Oncology Group (RTOG) definition considers as high-risk PC any T-stage plus Gleason score ≥ 7 and PSA 20–100 ng/mL, or a clinical T-stage ≥ T2c associated with Gleason score 8–10 and PSA <100 ng/mL [10]. Here, KLK3 is linked to pachyonychia congenita.