Other laboratory abnormalities include markedly elevated soluble IL-2 receptor alpha (sIL-2Rα), hypertriglyceridemia, increased lactate dehydrogenase (LDH), and inversion of the CD4/CD8 ratio, which together support a hyperinflammatory state and lymphoproliferative activity (Supplementary Table S3) [51]. This evidence concerns the gene CD8A and hypertriglyceridemia.