HSD17B10 and Choreoathetosis: This finding indicates that the pathogenic role of 17β-HSD10 in neurodegeneration is not limited to its so-called “mediation of Aβ neurotoxicity.” Reduced expression of 17β-HSD10 was also considered to result in the pathogenesis of X-linked mental retardation, choreoathetosis, and abnormal behavior (MRXS10) [60,61].