NPPB and hydrops fetalis: Biomarkers have also played a central role in HF risk stratification; elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, particularly above 125 pg/mL, have been associated with a 2.4-fold increased risk of incident HF, and its predictive value is enhanced when combined with high-sensitivity cardiac troponin [7,8].