ZFHX3 and cardioembolic stroke: Significant associations between the ZFHX3 variant (rs2106261; OR 1.19, 95% CI 1.11–1.27, and p ≈ 10−7) and the PITX2 variant (rs12041331; OR 1.39, 95% CI 1.29–1.49, and p ≈ 10−19) and cardioembolic stroke—lags that directly overlap with known AF risk loci—were confirmed by a large meta-analysis of GWAS data from over 30,000 cases and 43,000 controls in the METASTROKE consortium [29].