In conclusion, through a combination of metabolic regulation, antioxidants, stabilization of atherosclerotic plaques and anti-inflammatory properties, cardiac remodeling modulation, and endothelial function enhancement, the dual PPAR agonist SAR provides cardioprotective effects and is considered a promising therapeutic agent for a variety of cardiovascular disorders to be tested in clinical trials for its pleiotropic properties. This evidence concerns the gene PPARA and cardiovascular disorder.