Meanwhile, the miRNAs upregulated in the Mg AZ31+SPF group are involved in the regulation of constitutive signaling by aberrant PI3K in cancer, PI3K AKT signaling in cancer, PI5P, PP2A, and IER3 regulation of PI3K AKT signaling, negative regulation of the PI3K AKT network, FGFR2b ligand binding and activation, PIP3 activation of AKT signaling, negative regulation of FLT3, intracellular signaling by second messengers, activated point mutants of FGFR2, phospholipase C-mediated cascade, and FGFR2 signaling. This evidence concerns the gene IER3 and cancer.