Adipose tissue-associated IL-2 is also associated with overexpression of a variety of inflammatory markers, such as IL-8, IL-12a, IL-1β, C-C motif chemokine ligand 5 (CCL5), CCL15, TLR2, and an inflammatory macrophage marker (CD11c), inducing inflammation and insulin resistance [61]. This evidence concerns the gene IL1B and Insulin resistance.