SETD2 and obesity due to melanocortin 4 receptor deficiency: Moreover, obesity can regulate the mutation of oncogenes, such as Kirsten rat sarcoma virus (KRAS), epidermal growth factor receptor (EGFR), SET domain-containing 2 protein (SETD2), and BRCA1-associated protein 1 (BAP1), which also increases the risk of cancer development [90].