Another study also reveals that obesity induces a decreased expression level of PD-1, lymphocyte-activation gene 3 (Lag3), and T cell immunoglobulin and mucin domain-3 (Tim3) in tumor-infiltrating CD8+ T cells, resulting in CD8+ T cell dysfunction [75]. The gene discussed is HAVCR2; the disease is obesity due to melanocortin 4 receptor deficiency.