AMACR and neoplasm: Immunohistochemistry (IHC) with markers such as high-molecular-weight cytokeratins, p63, epithelial cell adhesion molecule (EPCAM), transforming growth factor (TGF)-beta, and alpha-methylacyl-CoA racemase (AMACR) helps assess the integrity of the basal cell layer, the myoepithelial layer, and its infiltration by the tumor.