The function of IGF-1 stimulates skeletal muscle hypertrophy and a shift to glycolytic metabolism by activating calcium–calmodulin-dependent calcineurin phosphatase (calcineurin A; 114105) and inducing nuclear factor of activated T cells, cytoplasmic 1 protein (NFATC1) (600489), which is postulated as an important factor in obesity prevention [6,11], It is a significant risk factor for the development of multiple pathologies, such as metabolic and cardiovascular diseases, various neoplasms, neurodegenerative disorders, and musculoskeletal system alterations [12]. This evidence concerns the gene IGF1 and obesity due to melanocortin 4 receptor deficiency.