NFKB1 and colonic neoplasm: Goyazensolide (5) and lychnopholide (7) showed promising activities against human colon cancer cell line HT-29, with IC50 values of 0.56 and 1.4 μM, respectively, but were also found to inhibit the NF-κB p65 at concentrations of 3.8 and 2.9 μM [29].