Of the sesquiterpene lactones investigated in our study, goyazensolide (5) was identified as a potent NF-κB inhibitor in the human colon cancer cell line HT-29, suggesting that the inhibition of NF-κB expression may sensitize HT-29 to apoptosis [52]. The gene discussed is NFKB1; the disease is malignant colon neoplasm.