Their anti-cancer activities range from influencing the sarcoplasmic reticulum Ca2+ ATPases (SERCA) via the inhibition of NF-κB, angiogenesis, metastasis, and the transcription factor STAT3 to the activation of the p53 signaling pathway and formation of reactive oxygen species (ROS) [46,47,48,49]. Here, STAT3 is linked to cancer.