A first metabolism superset was centered around bioenergetic metabolism and contained 7 pathways (‘Central carbon metabolism in cancer’, ‘Citrate cycle (TCA cycle)’, ‘Pyruvate metabolism’, ‘HIF-1 signaling pathway’, ’Pentose phosphate pathway’, ‘Glycolysis or Gluconeogenesis’, and ‘Butanoate metabolism’), 7 downregulated genes (SLC2A1, HK1, HK2, PFKFB3, LDHA, IDH2, and TKT), 8 increased metabolites (Ala, Asp, Leu, Phe, Pro, Tyr, and ATP) and 3 decreased metabolites (For, Acn, and BHB). This evidence concerns the gene PFKFB3 and cancer.